Endocrine Abstracts

Aim: To audit if fine needle aspiration of thyroid nodules are done as per the Royal College of Physicians Guidelines.Methods: We selected a list of 25 patients who had FNA of throid nodule over a 6 months period between July 2008 and December 2008 and analysed if the procedure had been done in accordance with current Royal College of Physicians guidelines for FNA Thyroid.Results:1. None of the cytopathology ...

ACTH insensitivity syndromes comprise a rare, and underrecognised, group of disorders, which include familial glucocorticoid deficiency (FGD) and triple A or Allgrove syndrome (ACTH insensitivity, alacrima, achalasia and neurological involvement). They are characterised by undetectable cortisol and very high circulating ACTH with resultant hyperpigmentation and are inherited in an autosomal recessive manner. Distinction between FGD and triple A syndrome may be difficult and is...

Background: A 5 year old boy who had been born at 29 weeks gestation presented to the paediatrics clinic with abnormally chubby cheeks. Our patient’s great-grandmother had had a similar appearance and his uncle had recently been diagnosed with giant cell granuloma of the jaw. After extensive imaging and genetic work-up, our patient was diagnosed with cherubism: a condition so named because of the resemblance to cherubic putti in Italian art.Cherubis...

Introduction: Multiple specialities teach and perform ultrasound-guided fine-needle aspiration biopsy (USG-FNA) of thyroid nodules, including Radiology, Endocrinology, and Pathology. Contrasts in cytopathology results might connect with various USG-FNA procedures just as contrasts in the knobs assessed. This study planned to play out a nitty-gritty investigation of USG-FNA results among these different showing administrations at a solitary scholarly clinical focus.<p class...

Background: For a thorough evaluation of the pituitary gland, it is important to understand its typical structure, including the physiological differences in size and form across age groups in both males and females.Objectives: To use magnetic resonance images to examine the size, shape, and average normal volume of the normal pituitary gland at various age groups in both genders (MRI).Material and methods: 200 individuals who unde...

This case illustrates a decision paradox on investigations (to exclude secondary hypercalcaemia) and treatment options (in unresponsive thyrotoxicosis despite supra-normal doses of carbimazole). A 56-year-old lady, who was referred with hyperthyroid symptoms and evidence of biochemical thyrotoxicosis, was also found to have symptomatic hypercalcaemia (constipation & polyuria). Investigations were as follows: FT4 >100 pmol/l, TSH <0.02 mU/l, TRAb positive, Ca 3.0 mmol/l...

Introduction: STAT5 proteins are components of the common growth hormone and interleukin-2 family of cytokine signaling pathway which is a critical molecule involved in growth hormone receptor (GHR) signal transduction, mediating the growth-promoting actions of the GHR. In addition to its role in GHR signal transduction, STAT5B is also involved in the immune system as an important mediator of interleukin-2 action and disruption of this signal transduction is responsible for T-...

Background: Celiac disease is frequently associated with type 1 diabetes mellitus, but is usually ill-defined and not usually suspected until the disease become advance.Aim: To study the prevalence, clinical profile and glycemic variability and the effect of gluten free diet on growth and diabetic control in celiac type 1 diabetes patients in a tertiary care referral centre in north India.Materials and method: Total of 256 patients...

Background: Diabetic ketoacidosis is characterized by biochemical tired of hyperglycemia, acidosis, and ketonemia. It remains a life threatening condition despite improvement in diabetic care, timely identification and intervention remains the backbone of treatment.Aim and objectives: i) To evaluate the clinical and biochemical prognostic markers in diabetic ketoacidosis. ii) To correlate the various prognostic markers with mortality in diabetic ketoacid...

Background: Juvenile hypothyroidism is very common problem in developing parts of world, and produces various skeletal manifestations. One of them is short stature and it is the most common reason for referral to endocrinologist.Aim and objectives: To study the prevalence of short stature in juvenile hypothyroidism, to study the various radiological manifestations of juvenile hypothyroidism and to study the impact of treatment on growth velocity and vari...